Persistent Pollutant May Promote Obesity

Tributyltin, a ubiquitous pollutant that has a potent effect on gene activity, could be promoting obesity.The chemical is used in antifouling paints for boats, as a wood and textile preservative, and as a pesticide on high-value food crops, among many other applications. Tributyltin affects sensitive receptors in the cells of animals, from water fleas to humans, at very low concentrations - a thousand times lower than pollutants that are known to interfere with sexual development of wildlife species. Tributyltin and its relatives are highly toxic to mollusks, causing female snails to develop male sexual characteristics, and it bioaccumulates in fish and shellfish. The harmful effects of the chemical on the liver and the nervous and immune systems in mammals are well known, but its powerful effects on the cellular components known as retinoid X receptors (RXRs) in a range of species are a recent discovery. When activated, RXRs can migrate into the nuclei of cells and switch on genes that cause the growth of fat storage cells and regulate whole body metabolism; compounds that affect a related receptor often associated with RXRs are now used to treat diabetes. RXRs are normally activated by signaling molecules found throughout the body.

Abdominal Obesity... MEDOWIN-slim Naturally

Abdominal fat comes in two different forms. Some of it is located in the fatty tissue just beneath the skin. This subcutaneous fat behaves like the fat elsewhere in the body; it's no friend to health, but it's no special threat either. Fat inside the abdomen is another story. This visceral fat, which is located around the internal organs, can damage your health.Scientists originally thought visceral fat was dangerous because it was linked to elevated stress hormones, which raise blood pressure, blood sugar levels, and cardiac risk. A newer explanation relies on the concept of lipotoxicity. Unlike subcutaneous fat, visceral fat cells release their metabolic products directly into the blood, so free fatty acids from visceral fat accumulate in the liver and other organs. This impairs the body's regulation of insulin, blood sugar, and cholesterol and leads to heart problems. A third hypothesis starts with the complex role of fat cells. In addition to hoarding excess energy, fat cells produce a large number of proteins that contribute to metabolic abnormalities, inflammation, and heart disease. These three explanations are not mutually exclusive; all may help account for the hazards of visceral fat.One way to evaluate body fat is to measure height and weight, then calculate body mass index (BMI). This is now the standard way to diagnose obesity. Another simple method uses the ratio of the waist and hip measurements. But many experts are turning to an even simpler technique: waist circumference. Because it involves one measurement instead of two, it's more accurate and reproducible. And new research suggests that this simple measurement is the best way to tell who is at risk for the serious consequences of obesity.So, what do you do about abdominal obesity? Remember the basics. The only way to reduce visceral fat is to lose weight

Obesity - Role In Erectile Dysfunction... MEDOWIN- slim naturally

Obese men with erectile dysfunction (ED) are shown to have low levels of hormones, such as testosterone. A correlation between certain conditions associated with obesity, particularly hypertension, are the most important determinants of obesity-related ED. The link between obesity and male potency dates from the Byzantine era, when it was thought that a large stomach impaired a man's ability to have sexual intercourse. This is particularly relevant today, as the prevalence of obesity has more than doubled in the last 25 years. Excess abdominal fat, cardiovascular disease, high blood lipids and type-2 diabetes characterize a condition known as metabolic syndrome, which has recently been associated with erectile dysfunction. obesity was significantly associated with a higher physical contribution to ED, while there was no difference seen with relational or psychological determinants. As the severity level of obesity increased, levels of testosterone decreased. Obese patients were also more likely to have abnormalities in penile blood flow. Psychological disturbances related to obesity did not seem to play a major role in developing obesity-related ED.

Six Newly Discovered Genes For Obesity... MEDOWIN-slim naturally

Obesity is known to increase the risk of chronic disorders, such as diabetes (type 2). An international team of scientists with German participation through the Helmholtz Zentrum München identified six new obesity genes. Gene expression analyses have shown that all six genes are active in brain cells. The international GIANT (Genetic Investigation of Anthropometric Parameters) consortium works on the discovery of obesity genes. So far, the scientists have analyzed two million DNA variations in 15 genome-wide association studies with a total of more than 32,000 participants. The hereby identified candidate genes were validated in 14 further studies including 59,000 participants. In addition to the FTO and MC4R genes already known, it was now possible for six more obesity genes to be identified: TMEM18, KCTD15, GNPDA2, SH2B1, MTCH2, and NEGR1. Gene expression analyses have shown that all six genes are active in brain cells. Also the previously known two obesity genes, FTO and MC4R, show a similar expression pattern; in case of the MC4R gene, a genotype-dependant influence on the behavior of appetite is already established. Scientists of the German National Genome Research Network (NGFN), Prof. H.-Erich Wichmann and Dr. Iris Heid from the Helmholtz Zentrum München, Institute of Epidemiology, who lead the German participation of this consortium, emphasize: "Definitely, the two main causes for obesity are poor nutrition and lack of physical activity. But the biology of these genes suggests genetic factors underlying the different reaction of people to lifestyle and environmental conditions." With the exception of the SH2B1 gene, which plays a role in the leptin signalling and thus in the regulation of appetite, none of the other five genes was hitherto discussed as obesity genes. Iris Heid and her collegue Claudia Lamina from the Ludwigs-Maximilians-Universität München are enthused: "The purely statistical approach of the genome-wide association analysis can depict new aspects of the biology of weight regulation, which were previously unanticipated."

Overweight - affects multi system,... MEDOWIN - Slim naturally

Blood pressure
High blood pressure (hypertension) occurs more frequently in overweight people. Since hypertension can result in varying degrees of damage to the brain (stroke) and kidneys (degeneration) as well as the heart, it is essential that hypertensive overweight patients lose weight.
Lungs
In overweight people, an increased body volume must be supplied with oxygen by lungs that have not correspondingly increased in their size. In addition, the presence of thick pads of fat in the abdomen restricts breathing. Anesthetic risk is increased in overweight patients. Being overweight can be a special problem for asthmatics.
Gall bladder
A significantly higher incidence of gallbladder disease is observed in overweight patients than in those of normal weight. In one study, 88% of the 215 patients operated on for gallstones were found to be overweight.
Diabetes
Diabetes is more common in overweight patients than in patients of normal weight. In one group of studies, 70 to 85% of diabetics had a history of obesity. When an overweight diabetic loses weight, his diabetes often improves.
Pregnancy and surgery
Overweight can be a factor in producing difficult and prolonged labor due to abnormal positioning of the fetus. This can cause fetal distress, which, in turn, may complicate labor and delivery. In addition, severely overweight women have more difficult pregnancies and an increased occurrence of maternal and infant deaths. Surgical procedures are more difficult in overweight individuals due to the very bulk of adipose tissues.
Joint disease
A vicious cycle is set up in overweight patients with arthritis of the hip, knees, or feet, or in those who suffer from a ruptured intervertebral disc. Increased weight leads to greater wear and tear on these joints, which may become more irritated and painful. The increased discomfort forces the patient to become less and less active, thereby favoring further gain in weight.
Atherosclerosis
Atherosclerosis is the deposit of fatty material in the lining of the arterial wall. In can result in the rupture of the blood vessel or in narrowing of these vessels, which may lead to stroke or heart attack. Studies show that there is a marked increase in the occurrence of atherosclerosis in overweight people.
Heart
As one gains weight, the heart must work harder to supply nutrients to all tissues of the body. The greater the body mass, the greater the strain on the heart. There is a higher incidence of heart disease in people who are overweight.
Hernia
Certain types of hernias, involving displacement of the upper part of the stomach into the chest cavity, are more prevalent in overweight individuals than in those of normal weight.
The omentum
Many overweight people assume that their pot-bellied appearance is due to not fat but to a protruding stomach. Actually, their shape is only partially due to the accumulation of fat under the skin; most of the bulge results from fat accumulation within the abdominal cavity - in the omentum.
Baby fat
Baby fat is not cute. When excess weight is gained during childhood, the number of fat cells in the body increases. Since the fat cells in the body increases. Since the fat cells developed in childhood remain throughout life, it becomes exceedingly difficult to lose weight as an adult.
Adipose tissue
Adipose (fat) tissue is composed of cells which are highly elastic and contain varying amounts of fatty deposits acquired via the bloodstream. The tissue is situated throughout the body - under the skin in protective pads covering vital organs, and in association with muscles. Excessive fat deposits are found in virtually all soft tissues and organs in overweight people. The degree of overweight depends upon the number of fat cells present and the amount of fat they contain. In the course of weight reduction, fat cell volume is decreased, but the number of fat cells remains constant.

Thank you Medowin

Smitha 29 years,Komalloor,Alleppey dist Kerala, has got tremendous result of loosing her 4.5 kgms of her body weight just within 28 days. She is very happy that she could regain her health and bodyshape. She told Doctor, all are saying "you must stop taking medowin otherwise you will get more slim". Anyway I am feeling very healthy . Thank you doctor.
This is one of several feed backs we are getting everyday.

MEDOWIN - Slim Naturally

MEDOWIN - Slim Naturally
Medowin helps to reduce obesity in a natural way and ofcourse in a safe way. Medowin is completely herbal and it corrects the fat metabolism of the body. It reduces the craving of food in obese. One of the main causes of obesity is imbalance in absorption and assimilation. Medowin corrects this imbalanceand helps the body to adjust itself to expel the unwanted fats through natural channels without loosing essential minerals. Medowin starts its action in the body within 35 days. Minimum course of this herbal product is 3 months. If the body weight is more than 90 kg 6 months course is indicated. Since it is 100% herbal it can be taken in age group and in any condition. Medowin is safe in diabetic patients , hypertensive patients, cardiac patients, lactacting mother , children etc and it can be taken along with any medicines whether it is allopathic or homeopathic.